There exists a Hungarian rifle called the GM6 Lynx. This semi-auto bullpup represents an attempt at making the comparably least bulky .50BMG rifle available. Although given the size of the cartridge, that’s a very tall order. It’s all relative.
Anyway, I bring this up because I find it interesting and not just for its own sake. My first thought to using this in fiction would be as an anti-monster gun, because it would be the comparably least clunky attempt to harm big beasties (given how the original King Kong eventually succumbed to lighter .30-06 bullets, a few people with these could probably take him down.) But then a different thought came to my mind. This gun came at the wrong time from the wrong country for fictional prominence.
See, men’s adventure writers unsurprisingly often focused on size and “exotic” qualities over practicality. Mack Bolan used a .460 Weatherby elephant gun. The Desert Eagle is actually reasonable compared to the infamously buggy Automag, but that was the weapon of choice before the former came into being. So my thought is “if a comparably small .50BMG rifle that wasn’t from a then-Soviet-aligned country existed at the height of the men’s adventure boom, you bet every action hero would be using it a lot.”
As it stands, a predecessor to the GM6 by the same manufacturer, the GM1 (which looks a lot more like the classic PTRD/M82 style .50 rifle), appeared in Phantom of Inferno, used by Ein on a sniper mission. The gun was almost as long as she was tall. It has since been used in fighting games as her super move.